Inside mRNA Vaccines a Human Molecule Diabolically Altered. Cambridge’s Alarming Study on M1Ψ Toxic Dangers
In the cover image, the Canadian researcher Jessica Rose, author of an excellent biochemical analysis of an article from the University of Cambridge commenting a study by some of its researchers on the toxicity of manipulated human nucleoside in mRNA genetic sera
by Fabio Giuseppe Carlo Carisio
«Well of course! Now that we know that billions of people’s cells might be making aberrant proteins, for unknown periods of time, we can simply sweep these people under the rug, ‘fix’ the product, and keep on makin’ money. Let’s go slidin’ down the slippery sequence slope of gene therapy straight to the Gates of hell».
With this phrase to be engraved in the history of the massive Covid vaccination campaign, the esteemed Canadian researcher, biochemist, immunologist and molecular biologist Jessica Rose (Source 1), author of multiple fundamental discoveries on the contamination of mRNA genetic sera, best describes the disturbing importance of an article published by University of Cambridge in relation to an enlightening scientific research which confirmed to the global scientific community the dangerous experimental use in the Pfizer-Biontech and Moderna mRNA vaccines of what we do not hesitate to define as the “Diabolical Molecule” because it is a biological human component modified twice in the laboratory.
This is the double alteration of Uridine transformed into Pseudourine with the first synthetic biochemical alteration and then into N1-methylpseudouridine initialed “m1Ψ” as an acronym for N1-methyl-Ψ in which the Greek letter “Psi” was used to name Psueudoridine .
Uridine is an organic compound, nucleoside, made up of the coupling of a molecule of ribose and one of uracil. Uracil is one of the two pyrimidine nitrogenous bases that form the nucleotides of RNA nucleic acid.
This manipulation was designed by the Hungarian biochemist Katalin Karikó, awarded the 2023 Nobel Prize for Medicine precisely for having laid the foundations of mRNA vaccines, in order to “deceive” human cells into recognizing the synthetic mRNA as harmless human RNA …
I apologize to the biochemistry experts for any transcription mistakes I may make trying to translate from a difficult chemical language the portentous scientific essence of the abundant technical quotations in the article published by Rose on her Substack, from which we will only extrapolate its introduction.
Martin: “Pseudouridine Killer in the Vaccines for Depopulation”
This analysis comes surprisingly providential as on Gospa News International we have just reported the summary of a conference by the famous patent expert David E. Martin in which he narrated in recent weeks the story of SARS-Cov-2 as a bacteriological weapon built in 58 years of military research on coronaviruses and that of mRNA vaccines, in his opinion, knowingly spread in a mass experiment for the search for vaccines against HIV-AIDS and cancer but also aimed at global depopulation.
In a very detailed article the American osteopath doctor Joseph Mercola wrote that «Martin points out that even if they don’t unleash any other bioweapons, the desired death toll may still be achieved, because they used pseudouridine in the mRNA shots, which is causing “turbo cancers”».
Because: «Pseudouridine suppresses cancer-controlling agents and promotes oncogenic activity in the body, and this has been known since 2018, so its inclusion was hardly an accident. It’s a conspiracy, alright. But not a conspiracy theory in the dismissive sense. It’s a global conspiracy by identifiable agents who have, for nearly 60 years, plotted to commit, and profit from, the greatest genocide the world has ever seen, while hiding behind the false veneer of “public health.”».
Well today, both the University of Cambridge and other authoritative scientists from around the world implicitly confirm that all those vaccinated with Covid mRNA with Moderna’s Spikevax and Pfizer-Biontech’s Comirnaty have been and continue to be unpaid and, above all, unaware human guinea pigs.
Precisely because of this altered nucleoside…
The Disturbing Article from Cambridge University
The comment by the researcher Rose
that we reported in the incipit of the article referred to the text of the University of Cambridge (Source 2) in relation to the study “N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting” by Mulroney et al. published on December 6, 2023 by Nature after more than a month of review.
«Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses» is the eloquent title of the scientific text published by the British university.
«The latest developments, led by biochemist Professor Anne Willis and immunologist Dr James Thaventhiran from the MRC Toxicology Unit at the University of Cambridge, build upon previous advances to ensure the prevention of any safety issues linked with future mRNA-based therapeutics. Their report is published today in the journal Nature» we read in the unsigned article.
«The researchers identified that bases with a chemical modification called N1-methylpseudouridine – which are currently contained in mRNA therapies – are responsible for the ‘slips’ along the mRNA sequence» adds the university website.
In collaboration with researchers at the Universities of Kent, Oxford and Liverpool, the MRC Toxicology Unit team «tested for evidence of the production of ‘off-target’ proteins in people who received the mRNA Pfizer vaccine against COVID-19. They found an unintended immune response occurred in one third of the 21 patients in the study who were vaccinated – but with no ill-effects, in keeping with the extensive safety data available on these COVID-19 vaccines».
Despite disturbing the article already appears biased as it is aimed at “minimizing” the adverse reactions, even lethal one, that are accumulating in pharmacovigilance systems around the world, which have been confirmed by an alarming article in the journal Science, by the regulatory bodies from all over the world (EMA, FDA, etc.) and which led Moderna and Pfizer-Biontech to include the risk of lethal myocarditis in the information leaflets of their genetic drugs…
British Study: “Incorrect mRNA Translation may Increase Toxicity”
But it is the same authors of the study whose first signatory is Thomas E. Mulroney (Source 3), associate researcher of the Toxicology Unit of the MRC in Cambridge, who wrote the shocking considerations from a biochemical point of view in the conclusions.
«We show that 1-methylΨ is a modified ribonucleotide that significantly increases +1 ribosomal frameshifting during mRNA translation and that cellular immunity to +1 frameshifted products can occur following vaccination with mRNA containing 1-methylΨ. To our knowledge, this is the first report that mRNA modification affects ribosomal frameshifting. Alongside this impact on host T cell immunity, the off-target effects of ribosomal frameshifting could include increased production of new B cell antigens».
And they further add:
«These findings are of particular importance to our fundamental understanding of how ribonucleotide modification affects mRNA translation, and for designing and optimizing future mRNA-based therapeutics to avoid mistranslation events that may decrease efficacy or increase toxicity».
We will not delve further into the technical references but return to the analysis published by Jessica Rose in her Substack, making an extreme summary of it and advising professionals to read the text full of important images.
Let’s start with the comment added under the research published by Nature by her together with David Wiseman, L. Maria Gutschi, David J. Speicher, Kevin McKernan.
Alongside the Canadian biologist they were already co-authors of the study “DNA fragments detected in the monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: exploratory dose-response relationship with serious adverse events” which induced the EMA to confess that Pfizer hid the use of the very dangerous SV40 gene in its vaccine, which can cause tumors.
The same research encouraged the bioimmunologist Robert Malone to denounce the presence of the antibiotic resistance gene in the Moderna one, pointing out also that the pharmaceutical company was aware of the tumor risks of mRNA biotechnology as reported in its own patent.
We have written extensively about these topics in three investigations, one of which – on antibiotic resistance gene – is a world exclusive.
Alarm of American Scientists for the New Research
Let us therefore see the content of the comment by Rose and colleagues (Source 1) on Cambridge’s research:
The paper provides evidence for the formation “off-target” or unintended proteins following vaccination with BNT162b2 due to frameshifting. Given the proposed mechanism, a similar problem is likely to exist for the Moderna product.
While the authors have not isolated samples of these proteins from vaccinated patients or animals, their existence is evidenced by the specific cellular immune responses elicited to frameshifted proteins the authors synthesized. It is not clear why B cell – antibody responses were not studied.
The authors state that “Although there is no evidence that frameshifted products in humans generated from BNT162b2 vaccination are associated with adverse outcomes.”
It is unclear how it is possible to make this statement, given:
• The small number of vaccinated subjects (n=21) providing samples.
• This was not a controlled trial.
• None of these subjects had reported undue effects of vaccination. Accordingly, the sample is subject to selection bias.
• The toxicology of these unintended proteins must be studied.
• The authors acknowledge the misdirected immunity “has huge potential to be harmful.”
Translated into simpler words, no one has verified the selection methods of the samples which may have been chosen precisely because they did not have serious adverse reactions.
Furthermore, in the interests of expertise we read that the two Cambridge scientists Thomas E. Mulroney and Anne E. Willis «are inventors of a pending patent application (2305297.0) relating to mRNA technology» while in the information on the authors it is discovered that Alexander J Mentzer works at the Wellcome Center for Human Genetics, University of Oxford.
Wellcome, with the Bill & Melinda Gates Foundation and the World Economic Forum, is among the founders of the Ngo CEPI (Coalition for Epidemic Preparedness Innovations) which has already launched the SKYCovion vaccine together with the London-based GSK, managed by CEO Emma Walmsley who is also director of Microsoft, and SK Bioscience.
But let’s go back to the analysis made by Jessica Rose on the Cambridge researchers’ study: «The authors write that N1-methylpseudouridine affects the fidelity of mRNA translation via ribosome stalling that induces frameshifting. Frameshifting results in the production multiple, unique and potentially aberrant proteins».
«The modified mRNAs for use in the COVID-19 products were codon-optimized for maximal protein expression in humans. Codon optimization, or synonymous codon replacement, rests on the idea that one can induce mutations throughout a gene of interest (like spike) based on an organism’s (like humans) codon usage bias, to increase translational efficiency and protein expression without altering the sequence of the protein. But, it is well-known that codon-optimization can lead to protein conformation, folding and stability problems».
The Canadian immunologist further notes:
«Codon optimization could affect protein conformation, folding and stability, change post-translational modification sites and even affect protein function. Different rates of translation by different tRNAs, including those that exhibit wobble base-pairing (a tRNA that can recognize multiple synonymous codons) may actually be critical for determining the rate of translation. The ribosome may slow and pause during elongation which may actually be necessary for proper protein folding. Therefore, codon optimization may disrupt the fine-tuned timing of translation and ultimately protein function».
The Prophetic Seneff Study on Autoimmune and Neurocerebral Damage
He then refers to other studies that had reported the dangers of this biochemical manipulation (Source 1):
«Codon optimization can also lead to misfolding of mRNAs due to increased Guanine/Cytosine (GC content). Please read McKernan et al.’s preprint, Xia et al.’s paper and Seneff et al.’s paper to learn more about potential problems relating to codon optimization and GC content changes. The latter group write: Synonymous codon replacement also results in a change in the multifunctional regulatory and structural roles of resulting proteins».
The risks to the human organism are clearly highlighted:
«There is, in fact, a significant enrichment of GC content (17% and 25% enrichments as per Pfizer and Moderna, respectively, as compared to SARS-CoV-2) as a result of the codon optimization that was done, and this can lead to “dysregulation of the G4-RNA-protein binding system and a wide range of potential disease-associated cellular pathologies including suppression of innate immunity, neurodegeneration, and malignant transformation”. Increased GC content significantly alters mRNA secondary structure as well, and this can also lead to ribosomal pausing or stalling».
These considerations were expressed in a study published by illustrious scientists such as Stephanie Seneff, Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA, Greg Nigh, Immersion Health, Portland, OR, USA, Anthony M. Kyriakopoulos, Nasco AD Biotechnology Laboratory, Department of Research and Development, Piraeus, Greece and Peter A. McCullough, for Health Foundation, Tucson, AZ, USA, which was the subject of enormous censorship by specialized medical journals but we published in Gospa News thanks to an excellent summary by Dr. Mercola.
Dangerous RNA Manipulation with N1-methyl-Ψ
Below are the quotes from Seneff et al. (Source 4) useful for understanding the connection with uridine modified in N1-methyl-Ψ: «The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein».
«However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance».
In the study entitled “Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs” the scientists added:
«These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health».
The late biologist Luc Montagnier, in a study published posthumously by his research friends Jean-Claude Perez and Claire Moret-Chalmin with a review contribution from Seneff biophysics, proved without a shadow of a doubt the correlation between killer prions caused by vaccines and rapid deaths for neurocerebral Creutzfeldt-Jacob disease, human mad cow disease.
In detail Seneff and the other scientists also refer to specific alterations:
«Impaired type I IFN signaling is linked to many disease risks, most notably cancer, as type I IFN signaling suppresses proliferation of both viruses and cancer cells by arresting the cell cycle, in part through upregulation of p53, a tumor suppressor gene, and various cyclin- dependent kinase inhibitors (Musella et al., 2017; Matsuoka et al., 1998). IFNα also induces major histocompatibility (MHC) class 1 antigen presentation by tumor cells, causing them to be more readily recognized by the cancer surveillance system (Heise et al., 2016)».
They then delve into the problem of the uridine molecule.
To understand its importance we report a note from Rose: «Pseudouridines (Ψs) are a normal and essential part of our biology. They have been called the 5th nucleotide, in fact, and “are a ubiquitous constituent of structural RNA (transfer, ribosomal, small nuclear (snRNA) and small nucleolar), and present in coding RNA, across the three phylogenetic domains of life”and “accounts for about 1.4% of all bases in human rRNAs”».
Here’s what Seneff and his colleagues wrote about vaccines:
«A breakthrough came when it was discovered experimentally that the mRNA coding for the spike protein could be modified in specific ways that would essentially fool the human cells into recognizing it as harmless human RNA. A seminal paper by Karikó et al. (2005) demonstrated through a series of in vitro experiments that a simple modification to the mRNA such that all uridines were replaced with pseudouridine could dramatically reduce innate immune activation against exogenous mRNA».
Cancer Risk pointed out by the Nobel Inventor of mRNA Vaccines
Precisely for this discovery, Hungarian researcher Katalin Karikó, long-time at Biontech, recently received the Nobel Prize for Medicine together with her American colleague Drew Weissman, although both warned of the dangers of the new mRNA biotechnology.
Medicine Nobel to mRNA Covid Vaccines’ Scientists, both Sponsored by Gates, Fauci and Zuckerberg
In particular, on January 6, Karikó declared to the German newspaper Welt (Source 5):
«Every day I receive many emails from people who write to me about their experiences. One woman wrote to me that two days after the vaccination she developed a large lump in her breast. Vaccination caused cancer, it was her conclusion. But the cancer was already there, only vaccination gave an extra boost to the immune system, so that the immune defense cells rushed in large numbers towards the enemy».
The Gospa News investigations on Turbo-Cancer based now on seven published scientific studies have highlighted a very strong correlation between mRNA gene sera and the appearance or reactivation of tumor phenomena with abnormal degeneration resulting in lethal outcomes.
Karikó herself adds: «Vaccination provides a strong boost to the immune system. It can happen that a dormant infection breaks out in people with an already weakened immune system. The extent to which this is the case for shingles will need to be examined more closely».
Gospa News did so by discovering 27 thousand cases of Herpes Zoster, in the European Union only, as adverse reactions to vaccines reported by EMA pharmacovigilance database even in children, who are more exposed to damage to the natural immune system as confirmed by recent research.
Let’s go back to Seneff’s conclusions:
«Andries et al. (2015) later discovered that 1-methylpseudouridine as a replacement for uridine was even more effective than pseudouridine and could essentially abolish the TLR response to the mRNA, preventing the activation of blood-derived dendritic cells. This modification is applied in both the mRNA vaccines on the market (Park et al., 2021)».
To put it simply, the dendritic cell plays the role of sentinel and if it senses the presence of a pathogen in the body, it stimulates the immune response of B and T lymphocytes, specific against that antigen. If its action is limited or suppressed, it may become incapable of dealing with viral or bacterial enemies but also tumor dangers.
Critical Role of Pseudouridine in mRNA Vaccines
A study published by Pedro Morais, Director (Pseudouridylation Technology) ProQR Therapeutics, Leiden, Netherlands, and by Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY, US, entitled “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines” highlighted the fundamental role of the laboratory alteration of this protein in the Comirnaty and Spikevax genetic sera (source 6).
«Both consisted of N1-methyl-pseudouridine-modified mRNA encoding the SARS-COVID-19 Spike protein and were delivered with a lipid nanoparticle (LNP) formulation. Because the delivery problem of ribonucleic acids had been known for decades, the success of LNPs was quickly hailed by many as the unsung hero of COVID-19 mRNA vaccines».
But the scholars, one of whom has a clear conflict of interest because he is director of the Pseudouridylation Technology project, have highlighted another very interesting fact:
«However, the clinical trial efficacy results of the Curevac mRNA vaccine (CVnCoV) suggested that the delivery system was not the only key to the success. CVnCoV consisted of an unmodified mRNA (encoding the same spike protein as Moderna and Pfizer-BioNTech’s mRNA vaccines) and was formulated with the same LNP as Pfizer-BioNTech’s vaccine (Acuitas ALC-0315). However, its efficacy was only 48%. This striking difference in efficacy could be attributed to the presence of a critical RNA modification (N1-methyl-pseudouridine) in the Pfizer-BioNTech and Moderna’s mRNA vaccines (but not in CVnCoV)».
However, the same researchers highlight a significant note:
«The intrinsic immunogenicity of non-modified mRNA was once considered a potential advantage for its use in vaccines (Ishii and Akira, 2005) as it would encode the antigen and concomitantly serve as an adjuvant while permitting a low dose. In fact, the unmodified COVID-19 mRNA vaccine candidate in late-stage clinical trials (CVnCoV, developed by Curevac) had a maximum dose of 12 µg».
Curevac was developed by Curevac NV of Tubingen, together with the Ngo CEPI founded by Bill Gates with Wellcome and WEF, which initiated an authorization process before the CHMP committee of the European Medicines Agency (EMA) but withdrew it due to its low efficacy on October 12, 2021 (source 7) in view of the arrival of a new pharmacological product developed with GSK financed by Gates himself.
Here is another cryptic phrase in which we talk about the “safety” of vaccines, implicitly implying that it is not clear in the current vaccines which therefore make all those who take them into “human guinea pigs” from the laboratory as the immunologist Rose clearly highlights in her final bioethical considerations.
Rose: “Unpredictable Health Effects of Manipulated Codons”
«Ehden Biber also wrote a great article about the pitfalls of codon optimization that you can read here. In a Nature article published in 2011 entitled: “Breaking the silence”, the author writes on the potential danger of fiddling with codons in therapeutic proteins whereby it “could have unpredictable effects on people’s health”»
Rose wrote in her comment on the Cambridge research quoting many sentences by scientific journalist Alla Katsnelson which we report below.
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In detail, the Canadian researcher adds:
«She points to a study where the authors show that a synonymous codon change found in the most common form of cystic fibrosis results in mRNA misfolding. (Keep this in mind.) She also points out that in the context of the multi-drug resistance 1 gene (MDR1) (the gene that encodes P-glycoprotein), that a codon change may interfere with the pauses that characterize RNA passing through the ribosome, thereby changing how the growing amino acid chain folds».
«But perhaps the most timely and spine-tingly relevant statement in this article is found at the end, and I quote: “At the moment, companies developing recombinant therapies must verify that the DNA sequence designed by their scientists is the one that’s producing their proteins, but they aren’t required to note how different that is from the native genetic code”».
We do not have any guidance with regard to the [DNA] sequence,” Kimchi-Sarfaty notes.
While it was the Italian bioimmunologist Mauro Mantovani who demonstrated how the “double Proline” inserted in mRNA vaccines makes the toxic Spike protein dangerously persistent in the human body.
«That’s one piece of data that could be tracked by the system she is proposing. Such knowledge, in turn, could ultimately help define better strategies for optimization and possibly even make biologic drugs safer for people» adds Alla Katsnelson while the immunologist asks herself a question:
«I wonder if the FDA ever took her advice to track the differences in codons and the resulting potential adverse effects?»
Therefore Rose quoted the article which we analyzed before:
«In addition to our comment on the Nature paper, a University of Cambridge write-up entitled: Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses was penned. They make it clear that the most relevant conclusion from the Nature paper is that we can make more products similarly insanely dangerous as the ones pumped into billions of bodies because we can simply ‘reduce the production of frameshifted products’ by ‘synonymous targeting of slippery sequences’».
So she wrote her milestone sentence:
«Well of course! Now that we know that billions of people’s cells might be making aberrant proteins, for unknown periods of time, we can simply sweep these people under the rug, ‘fix’ the product, and keep on makin’ money. Let’s go slidin’ down the slippery sequence slope of gene therapy straight to the Gates of hell».
Moderna AWARE that mRNA Jabs cause CANCER due to DNA Fragments. Malone Unveils Patent
The Canadian molecular biologist concludes before going into detail about a biochemical analysis that is too technical for non-experts:
«The manufacturers might have thought to explore options to prevent potentially harmful responses from their products prior to injecting billions of people with them. It is criminal that these products continue to be forced onto newborns and infants by mandate, to this day».
And then she report an emblematic quote about the risks of “Fooling with Mother Nature” by an evolutionary cell biologist at the University of Chicago: “Please do not monkey with these sites; they are optimized for some reason”, in reference to codon bias in mammals.
Fabio Giuseppe Carlo Carisio
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MAIN SOURCES
SOURCE 1 – JESSICA ROSE – That Substack about N1-methylpseudouridines and frameshifting
SOURCE 3 – NATURE – N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
SOURCE 6 – FRONTIERS IN – The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
SOURCE 7 – EMA ends rolling review of CVnCoV COVID-19 vaccine following withdrawal by CureVac AG
