Breaking Study on mRNA COVID VACCINES: Higher TURBO-CANCER Risks due to Anomalous RNA:DNA Hybrid Residual found in the Pfizer and Moderna Vials
In the cover image: the Canadian bioimmunologist Jessica Rose
by Fabio Giuseppe Carlo Carisio
American genomics expert Kevin McKernan and Canadian bioimmunologist Jessica Rose were among the first to report the presence of billions of anomalous plasmids and DNA fragments in the mRNA COVID-19 vaccines, warning of dangerousness on this anomalous contamination.
This subsequently prompted Florida Surgeon General Joseph A. Ladapo to call for the suspension of Pfizer and Moderna’s products, precisely because such “waste” from the production process of these “gene therapies” poses a high risk of toxicity that can even trigger devastating forms of turbo-cancer, an adverse reaction to mRNA vaccines that has now entered the medical and scientific literature.
The VIDEO in which McKernan explained the Dangerouness of DNA Contamination inside mRNA Vaccines
Researchers McKernan and Rose discovered something even more alarming in a new study published on Zenobo
The two researchers have discovered something even more alarming in a new study published in a pre-print on Zenodo in December 2025 and titled “RNA:DNA hybrids survive digestion in mRNA vaccine manufacturing (link in the sources at the bottom of the article)
The amount of DNA residues appears to be even more serious and elevated than that already reported, exceeding the alert threshold, according to the same regulations regulating biotechnology for the production of messenger RNA genetic serums imposed by the FDA (Food and Drug Administration).
Not only that. It would also be linked to a continuous reproduction of the toxic Spike protein, which, according to Big Pharma predictions endorsed by government health authorities in Western countries, from the US to the UK, from Australia to the European Union, should have remained circulating in the blood for only the 36-48 hours necessary to trigger the antibody reaction for the supposed immunization (the journal Science has in fact published an article explaining why current vaccines are completely ineffective).
But dozens of studies, including a pioneering one by Italian bioimmunologist Mauro Mantovani, have instead confirmed the persistence of this harmful protein in the human body of vaccinated individuals for up to two years, further highlighting a disastrous impact on the immune system, with numerous serious autoimmune diseases in the brain, heart, and other vital human organs…
Why are these additional DNA residues present? And why weren’t they found earlier? McKernan and Rose explain this well in the abstract of their study, conducted with data analyst Charlie Rixey.
«The process of mRNA vaccine manufacturing relies on proper DNA digestion following an in-vitro transcription reaction to remove residual contaminating DNA from the plasmid backbone from the process. To assess the quality and quantity of potential DNA impurities in mRNA vaccines, we analyzed unopened, cold-chain compliant vaccine lots for residual DNA contamination using quantitative PCR (qPCR), RNase A/Qubit fluorometry, and Oxford Nanopore sequencing from two Pfizer and three Moderna vials».
DNA digestion is induced by an enzyme called deoxyribonuclease, or DNase. The researchers reported that in all cases examined, the enzyme did not completely destroy the sequences.
But this additional residue, which therefore increases the number of DNA fragments already detected, can only be detected with a very sophisticated process that is not commonly used.
Some DNA sequences hybridize with corresponding RNA transcripts, which carry the genetic information of the DNA used for protein synthesis. According to the authors, these RNA:DNA hybrids are significantly more resistant to DNase I digestion than typical double-stranded DNA.
The spike gene region is particularly prone to forming such hybrids
Because the spike gene region is transcribed into mRNA in large quantities, it is particularly prone to forming such hybrids.
«We compared spike-region amplicons and plasmid-vector amplicons to distinguish between DNA contaminant as double stranded DNA (dsDNA) versus RNA:DNA hybrids. qPCR assays revealed more than a 100-fold discrepancy in quantitation between dsDNA with RNA:DNA hybrids consistent with uneven DNase I digestion efficiency during mRNA vaccine manufacturing» McKernan, Rose, and Rixey explain more technically in the abstract.
Let’s remember that the safety issue with COVID-19 vaccines isn’t related to weight, but to the number of DNA fragments: smaller fragments pose a greater risk of DNA being integrated into existing cells, as already confirmed by an Italian reseach.
In this study, however, Kevin McKernan and Jessica Rose found a way to identify and mitigate this problem.
«Indeed, treatment of vaccines with DNase I-XT resulted in 100-1000X higher degradation of spike DNA, particularly in plasmid regions that form RNA:DNA hybrids.Together these results indicate that residual DNA testing which relies on a single qPCR for dsDNA fails to accurately quantify impurities, and that treating vaccine preparations with DNase I-XT during the manufacturing process may improve the quality by reducing contamination due to RNA:DNA hybrids» they conclude.
Pfizer Hid Residual DNA Data
McKernan, chief scientific officer and founder of Medicinal Genomics, first raised concerns over DNA contamination in COVID-19 vaccines in 2023.
That’s when his lab sequenced Moderna and Pfizer’s COVID-19 vaccines and found the presence of residual DNA that he accused Pfizer of deleting from the data the company gave regulators.
If you’d like to learn more about this topic, read the article below published by The Defender – Children’s Health Defense (partial funder of the research). It also includes interviews with the three scientists.
Fabio Giuseppe Carlo Carisio – Gospa News director
Researchers Find Residual DNA, Not Detected by Standard Tests, in mRNA COVID Vaccines
A new laboratory analysis of commercially available mRNA COVID-19 vaccines found that residual DNA fragments — including sequences linked to the spike protein gene — remain in the final vaccine products.
According to the researchers, the DNA fragments exist in forms that standard regulatory testing methods don’t typically detect.
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The researchers concluded that commonly used quality-control tests can underestimate total residual DNA by more than 100-fold, because the tests fail to detect DNA bound in RNA:DNA hybrid structures.
The study, published in a preprint authored by Kevin McKernan, Charles Rixey and Jessica Rose, Ph.D., examined unopened, “cold-chain compliant” Pfizer and Moderna vaccine vials using multiple analytical techniques.
A new study partially funded by Children’s Health Defense found residual DNA in Pfizer and Moderna COVID-19 mRNA vaccines.
Brian Hooker, Ph.D., chief scientific officer for Children’s Health Defense, which partially funded the research, told The Defender that having this type of genetic code in the vaccines’ lipid nanoparticles, which can easily cross cell membranes, is “dangerous indeed.”
When the vaccines were designed, the code for the spike protein was meant to express itself in the body in a targeted location for only about two weeks, Hooker said.
“However, this exogenous DNA can more easily disperse through the body and continue to both replicate and express episomally, making humans into genetically modified spike protein production factories,” Hooker said.
Hooker said the study may help explain some widespread clinical findings, “given that some vaccinated patients have been reported to continue to produce spike protein for periods as long as two years following their last COVID shot. This doesn’t even include the insertional effects that this additional exogenous DNA may have, leading to many different disorders, including cancer.”
Manufacturers ‘must have known’ residual DNA remained present
McKernan, chief scientific officer and founder of Medicinal Genomics, first raised concerns over DNA contamination in COVID-19 vaccines in 2023.
That’s when his lab sequenced Moderna and Pfizer’s COVID-19 vaccines and found the presence of residual DNA that he accused Pfizer of deleting from the data the company gave regulators.
McKernan’s lab tested the vaccines and found that instead of containing only mRNA, the Pfizer vaccines also contained DNA plasmids — small, circular, double-stranded DNA molecules distinct from a cell’s chromosomal DNA.
McKernan explained that to manufacture mRNA vaccines, labs use a process called “in vitro transcription” to produce the necessary RNA molecules.
To produce the RNA molecules, the scientists design a DNA template that triggers the production of the RNA sequence they want. An enzyme that recognizes this signal then copies the DNA into RNA.
However, to function properly, the DNA in the template needs to be amplified. For the clinical trials, Pfizer amplified DNA using PCR (polymerase chain reaction), a method it called “Process 1,” which created a clean version of DNA to make the RNA.
However, Process 1 was expensive. So to mass-produce vaccines for the public, Pfizer used “Process 2,” which used a different method to amplify the DNA. Process 2 is cheaper and easier, but runs the risk of introducing sequences that weren’t present in the original DNA.
McKernan called this switch from Process 1 to Process 2 a “bait and switch.” In a recent Substack video, he said the change was “a premeditated move.”
“You can tell what their intentions are by what assays they built,” he said. “And you can see by what they did that their plan from the start was to always use Process 2.”
Researchers: “The enzyme didn’t completely destroy the DNA sequences“
Manufacturers are required to digest and remove those sequences, which they did in this case using an enzyme called deoxyribonuclease or DNase.
However, in the preprint study, the researchers reported that in all cases they examined, the enzyme didn’t completely destroy the sequences.
“We proved a theory as to why and how the DNA got into the Moderna and Pfizer vials, in this new paper,” co-author Rose told The Defender. “There is DNA in every single vial tested to date. This has been reproduced in multiple labs across the world using multiple techniques. And the DNA came from hybridized RNA:DNA as a part of the Process 2 up-scaling process.”
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Rose added:
“These hybrids were not degradable by the enzyme the manufacturers chose to use to clean out residual DNA as the final step in the process, and they must have known this because it is known in the space that the enzyme they selected does not degrade hybrids. It’s scandalous what they did.”
Regulators use wrong safety limit, wrong tool to look for DNA fragments
Regulatory guidance generally limits residual DNA to 10 nanograms per dose. However, the authors said DNase does not digest all DNA equally.
On Substack, McKernan explained the 10-nanogram limit is outdated because it was created based on the assumption that residual DNA is “naked DNA,” which degrades quickly. But the DNA in COVID-19 vaccines is encapsulated in the lipid nanoparticle, so it doesn’t degrade as fast.
The safety issue with COVID-19 vaccines isn’t related to the weight, but to the number of DNA fragments — more fragments present a greater risk for that DNA to be integrated into existing cells.
Some DNA sequences hybridize with their corresponding RNA transcripts, which carry genetic information from DNA used for building proteins. These RNA:DNA hybrids are significantly more resistant to “DNase I digestion” than typical double-stranded DNA, according to the authors.
Because the spike gene region is transcribed into mRNA in large quantities, it is particularly prone to forming such hybrids.
Even though manufacturers are aware of this issue, regulatory testing typically relies on a single lab technique that amplifies and measures a specific DNA sequence, called a “qPCR assay.” That method is used only to target the kanamycin (KAN) resistance gene — a plasmid region that is not transcribed and is highly sensitive to DNase digestion.
According to the study, this approach creates a systematic bias: the DNA that is easiest to destroy is also the DNA that is measured, while more resistant regions go largely uncounted.
On Substack, McKernan said this was by design. “The assays they designed were designed not to find things.”
CHD Senior Research Scientist Karl Jablonowski said, “Regulators leveraged ‘just one assay target for vaccine sponsor quality control. They didn’t verify quality, nor did a third party.”
Because of that approach, “Those who stood to profit from the vaccines designed the test and tested the quality,” Jablonowski said. “They chose a test that was least likely to yield a bad outcome. A perfectly usable and validated alternative was already in their toolbox, but the results may have halted the entire enterprise.”
DNA levels vary by more than 100-fold depending on the test used
FULL ARTICLE CONTINUES HERE ON THE DEFENDER
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RNA:DNA hybrids survive digestion in mRNA vaccine manufacturing
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